| Field | Specification |
|---|---|
| Alternative names | Dosulepin; Dothep |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C19H21NS |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Dothiepin, also known as Dosulepin or Dothep, is an antidepressant with sedative/anxiolytic activity that preferentially inhibits noradrenaline uptake over serotonin uptake. It facilitates noradrenergic neurotransmission by inhibiting neuronal uptake and also acts as a histamine H1-receptor antagonist without cardiotoxicity. It exhibits significant analgesic activity in psychogenic facial pain, idiopathic fibromyalgia syndrome, and rheumatoid arthritis[1]. It is supplied as a white to light yellow solid (C19H21NS, MW 295.44) at 98.50% purity.
Physical & Chemical Properties
| CAS Number | 113-53-1 |
|---|---|
| Molecular Formula | C19H21NS |
| Molecular Weight | 295.44 g/mol |
| Purity | 98.50% |
| Appearance | Solid |
| Color | White to light yellow |
| SMILES | CN(C)CC/C=C1C2=CC=CC=C2SCC3=CC=CC=C/13 |
| Signaling Pathway | GPCR/G Protein; Neuronal Signaling; Immunology/Inflammation |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
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