| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C16H14ClN5O2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
DQn-1 is a potent antifolate active against Mycobacterium tuberculosis (Mtb), with a MIC90 of 0.03 μM. It directly inhibits DHFR enzyme activity, showing IC50 values of 8.7 nM against the Mtb enzyme and 7.6 nM against the human DHFR enzyme[1]. It has a molecular formula of C16H14ClN5O2 and a molecular weight of 343.77 g/mol.
Physical & Chemical Properties
| CAS Number | 57343-54-1 |
|---|---|
| Molecular Formula | C16H14ClN5O2 |
| Molecular Weight | 343.77 g/mol |
| SMILES | O=C(C1=CC=C(NCC2=CC=C3N=C(N)N=C(C3=C2Cl)N)C=C1)O |
| Signaling Pathway | Anti-infection |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
DQn-1 inhibits Mycobacterium tuberculosis with MIC90 values of 0.03 μM and 1 μM, respectively[1].
In Vivo
In mice, DQn-1 (5-10 mg/kg; p.o. for 8 days) produces no detectable significant reduction in Mtb burden[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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