| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C44H86NO9PS |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
DSPE-Thiol is a modified phospholipid bearing a reactive thiol (-SH) group and two saturated stearoyl chains, used mainly for liposome and nanoparticle bioconjugation. It facilitates attachment of targeting ligands, membrane stabilization, and formation of covalent bonds[1]. It is supplied as a white to off-white solid (C44H86NO9PS, MW 836.19) at 80.0% purity.
Physical & Chemical Properties
| CAS Number | 144735-82-0 |
|---|---|
| Molecular Formula | C44H86NO9PS |
| Molecular Weight | 836.19 g/mol |
| Purity | 80.0% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | CCCCCCCCCCCCCCCCCC(OC[C@](OC(CCCCCCCCCCCCCCCCC)=O)([H])COP(OCCNC(CCS)=O)(O)=O)=O |
| Solubility | In Vitro: DMF: 2 mg/mL (2.39 mM; Requires sonication and warming and heat to 60°C) |
| Storage | -20°C, protect from light, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMF | 2 mg/mL (2.39 mM) | requires sonication and warming and heat to 60°C |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); protect from light, stored under nitrogen; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
DSPE-Thiol, a thiol-functionalized phospholipid and precursor for nanoparticle coating, acts as a building block in synthesizing pH-sensitive phospholipid-hydrazone-PEG conjugates[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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