| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C58H70N4O15 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
dTAG-13-NEG serves as a negative control for dTAG-13, a PROTAC-based heterobifunctional degrader that selectively degrades FKBP12 F36V in cells expressing FKBP12F36V fused in-frame with a protein of interest[1][2]. It is supplied as a white to off-white solid (C58H70N4O15, MW 1063.19) at 99.94% purity.
Physical & Chemical Properties
| CAS Number | 2451573-90-1 |
|---|---|
| Molecular Formula | C58H70N4O15 |
| Molecular Weight | 1063.19 g/mol |
| Purity | 99.94% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=C1C2=C(OCCCCCCNC(COC3=C(C=CC=C3)[C@@H](CCC4=CC(OC)=C(C=C4)OC)OC([C@H]5N(CCCC5)C([C@H](C6=CC(OC)=C(C(OC)=C6)OC)CC)=O)=O)=O)C=CC=C2C(N1C7C(N(C(CC7)=O)C)=O)=O |
| Signaling Pathway | PROTAC |
| Solubility | In Vitro: DMSO: 100 mg/mL (94.06 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | -20°C, sealed storage, away from moisture and light. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (94.06 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture and light; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
PROTACs consist of two different ligands joined by a linker: one ligand binds an E3 ubiquitin ligase and the other binds the target protein. PROTACs make use of the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Data provided by the manufacturer.
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