| Field | Specification |
|---|---|
| Target | |
| Alternative names | Double homeobox 4, Double homeobox 10, DUX10, Double homeobox protein 4/10, DUX4L, DUX4L1 |
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| Reactivity | |
| Applications | |
| Immunogen | C-terminal 76 amino acids of Human DUX4 with glutathione-s-transferase (gst) tag |
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DUX4 (Double Homeobox 4) is a transcription factor implicated in gene regulation during early development. In adult tissues, aberrant expression of DUX4 is associated with toxic gain-of-function effects, particularly in facioscapulohumeral muscular dystrophy (FSHD).
Recent studies suggest that DUX4 may also contribute to neurodegenerative processes by activating stress response genes, disrupting RNA metabolism, and inducing apoptosis. Its expression in differentiated tissues, including skeletal muscle and potentially the nervous system, highlights its pathological relevance beyond muscular dystrophy.
DUX4’s ability to modulate transcriptional networks and trigger cell death pathways positions it as a candidate for further investigation in neurodegeneration, especially in disorders involving epigenetic dysregulation and inflammatory signaling.
1 µg/ml of SMC-192 was sufficient for detection of DUX4 in 20 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-mouse IgG: HRP as teh secondary.
Cite this product varies by variant:
- SMC-192D — Size: 100 ug: DUX4 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-192D, RRID: AB_10964369)
- SMC-192D-A390 — Size: 100 ug: DUX4 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-192D-A390, RRID: AB_2699025)
- SMC-192D-A488 — Size: 100 ug: DUX4 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-192D-A488, RRID: AB_2699026)
- SMC-192D-A594 — Size: 100 ug: DUX4 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-192D-A594, RRID: AB_2699028)
- SMC-192D-APC — Size: 100 ug: DUX4 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-192D-APC, RRID: AB_2699034)
- SMC-192D-BI — Size: 100 ug: DUX4 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-192D-BI, RRID: AB_2699035)
- SMC-192D-FITC — Size: 100 ug: DUX4 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-192D-FITC, RRID: AB_2699036)
- SMC-192D-HRP — Size: 100 ug: DUX4 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-192D-HRP, RRID: AB_2699037)
- SMC-192D-PCP — Size: 100 ug: DUX4 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-192D-PCP, RRID: AB_2699039)
- SMC-192D-RPE — Size: 100 ug: DUX4 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-192D-RPE, RRID: AB_2699040)
- SMC-192S — Size: 12 ug: DUX4 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-192S, RRID: AB_10964369)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
2. Dixit M., et al., (2007) Proc. Natl Acad Sci. USA. 104(46): 18157-18162.
3. Kowaljow V., et al. (2007) Neuromuscl Disord. 17(8): 611-623.
4. Lemmers R., et al. (2010) Science Express. 329(5999): 1650-1653.
5. Snider L., et al. (2010) PLoS Genetics. 6:1-14.
