| Field | Specification |
|---|---|
| Alternative names | N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride, dihydrate |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C₂₁H₂₇N₃O₃S · 2HCl · 2H₂O |
| Purity | |
| Bioactivity | Inhibitor |
| Activity | |
| Solubility | Soluble in water (100 mg/ml) and warm DMSO (25 mg/ml) |
| SMILES | |
| InChIKey | |
| Form | White solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
E-4031 is a selective blocker of hERG potassium channels, which play a critical role in cardiac repolarization. In neuroscience, hERG channels have been implicated in neuronal excitability and neurodevelopmental disorders. By binding to open hERG channels, E-4031 modulates potassium currents and may influence neuronal firing patterns. Its ability to alter ion channel dynamics makes it a useful tool in studying electrophysiological properties of neurons and potential channelopathies.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302-H315-H317-H318-H335
Precautionary Phrases:
P261-P280-P305 + P351 + P338
E-4031 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-317)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Perrin M.J., et al. (2008) Prog Biophys Mol Biol. 98: 137-148.
3. Sanguinetti M.C., Jurkiewicz N.K. (1990) J Gen Physiol. 96: 195-215.
4. Spector P.S., Curran M.E., Keating M.T., and Sanguinetti M.C. (1996) Circ Res. 78: 499-503.
5. Miyake K., et al. (1990) J Med Chem. 33: 903.
