| Field | Specification |
|---|---|
| Expression System | |
| Form | Liquid |
| Product Type | |
| Reporter | |
| Storage | |
| Target |
Scientific Background
Sudan Virus (SUDV, formerly Sudan Ebola virus) is a member of the Ebolavirus genus classified as a BSL-4 pathogen. SUDV causes hemorrhagic fever with case fatality rates of 40–65%. Critically, antibodies and vaccines developed against Zaire EBOV (EBOV) typically show limited cross-protection against SUDV due to divergence in the viral glycoprotein (GP). The 2022 SUDV outbreak in Uganda highlighted the urgent need for SUDV-specific countermeasures and safe research tools for studying SUDV entry.
Product Description
Filovirus
This HA-SUDV VLP is a hybrid alpha-pseudovirus assembled from Sudan Virus structural proteins (GP, VP40, NP) with an alphavirus-derived reporter RNA payload. BSL-2 safe. Available with Firefly luciferase, GFP, or RFP reporter.
Product Specifications
| Catalog Number | 0571-PP-002 |
|---|---|
| Virus Strain | Sudan Virus (SUDV) |
| Structural Proteins | GP (glycoprotein), VP40 (matrix protein), NP (nucleoprotein) |
| Reporter Payload | Alphavirus-derived self-replicating RNA encoding Firefly Luciferase, GFP, or RFP |
| Particle Type | Single-cycle alpha-pseudovirus (BSL-2 safe) |
| Form | Liquid |
| Size | 1X Concentrated: 25 × 200 µL (~100 wells per 96-well plate) |
| Storage | -80°C. Avoid repeated freeze-thaw cycles. |
Applications
- Sudan Virus pseudovirus transduction of target cells for viral entry studies
- Rapid anti-SUDV drug and entry inhibitor screening
- Rapid anti-SUDV neutralizing antibody screening and IC50 determination
Safety & Handling
Sudan Virus is antigenically distinct from Zaire Ebola virus — EBOV-targeted antibodies and vaccines generally do not cross-neutralize SUDV. SUDV-specific pseudovirus tools are essential for evaluating SUDV-specific countermeasures, particularly given the 2022 SUDV outbreak in Uganda that highlighted gaps in SUDV preparedness.
Yes. HA-SUDV and HA-EBOV (BHV20900042) can be used in parallel assays to evaluate cross-species neutralization potency of antibodies targeting conserved filovirus GP epitopes, or to confirm species-specific antibody responses.
BSL-2. HA-SUDV is a single-cycle pseudovirus that cannot produce infectious Sudan Virus. Standard BSL-2 precautions apply.
Need a different reporter, pack size, or bulk volume? BioHippo works directly with IBT Bioservices to support custom and large-volume requests. Contact us for a quote or to discuss your project requirements.
Looking for matching antigen proteins, antibodies, or other coronavirus/filovirus research reagents? Contact BioHippo support for recommendations.
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