| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, MCI-186 |
| Cas No. | |
| Form | Light Yellow Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 100 mM in DMSO |
| Source | Synthetic |
| Storage |
Edaravone is a free radical scavenger and antioxidant that has demonstrated neuroprotective effects in models of ischemic stroke and neurodegeneration. It mitigates oxidative stress by inhibiting lipid peroxidation and the lipoxygenase pathway, thereby preserving neuronal integrity. Edaravone has been shown to protect dopaminergic neurons from MPTP-induced neurotoxicity, a model of Parkinson’s disease. Its ability to cross the blood-brain barrier and reduce reactive oxygen species makes it a valuable agent in the treatment of neurodegenerative conditions characterized by oxidative damage and mitochondrial dysfunction.
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
- R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
- R62 - Possible risk of impaired fertility
- R68 - Possible risk of irreversible effects
Hazard Phrases:
H302-H315-H319-H335
Precautionary Phrases:
P261-P305 + P351 + P338
Edaravone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-152)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Yuki S., and Koqure K. (1997) Mol Chem Neuropathol. 32(1-3): 123-128.
