| Field | Specification |
|---|---|
| Target | |
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| Molecular weight | |
| Molecular formula | C12H15FN5O12P3 |
| SMILES | |
| Storage | |
| Shipping | |
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Compound Overview
EFdA-TP is a potent nucleoside reverse transcriptase (RT) inhibitor that blocks RT-catalyzed DNA synthesis, acting as an effective immediate or delayed chain terminator (ICT or DCT). It inhibits HIV-1 RT through multiple mechanisms[1]. It has the molecular formula C12H15FN5O12P3 and a molecular weight of 533.19 g/mol.
Physical & Chemical Properties
| CAS Number | 950913-56-1 |
|---|---|
| Molecular Formula | C12H15FN5O12P3 |
| Molecular Weight | 533.19 g/mol |
| SMILES | O=[P](O[P](O[P](O)(O)=O)(O)=O)(O)OC[C@]1(O[C@@](C[C@@H]1O)([H])N2C3=NC(F)=NC(N)=C3N=C2)C#C |
| Target | HIV-1 |
| Signaling Pathway | Anti-infection; Cell Cycle/DNA Damage |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
RT-catalyzed DNA synthesis is inhibited by EFdA-TP (0.05-10 μM; for 15 min), which acts as either an ICT or a DCT[1]. As a translocation-defective RT inhibitor, EFdA-TP can block RT and markedly slow DNA synthesis, which makes it a de facto immediate chain terminator. EFdA-TP can also act as a delayed chain terminator, permitting incorporation of one more dNTP before DNA synthesis is blocked[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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Structural and Mechanistic Basis of F227C-Mediated Hypersusceptibility to Islatravir in HIV-1 Reverse Transcriptase. bioRxiv 2026 Jun 10:2026.06.08.730881. PMID: 42327331
