| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C25H18N4O3 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
EGFR/BRAFV600E-IN-3 inhibits EGFR, BRAFV600E and EGFRT790M, with IC50 values of 57 nM, 68 nM and 9.70 nM, respectively. It induces apoptosis and displays antioxidant activity[1]. It has the molecular formula C25H18N4O3 and a molecular weight of 422.44 g/mol.
Physical & Chemical Properties
| Molecular Formula | C25H18N4O3 |
|---|---|
| Molecular Weight | 422.44 g/mol |
| SMILES | O=C1NC2=C(C=C(OC)C=C2)C(N3N=NC(C(C4=CC=CC=C4)=O)=C3C5=CC=CC=C5)=C1 |
| Signaling Pathway | JAK/STAT Signaling; Apoptosis; Protein Tyrosine Kinase/RTK |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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