| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C24H16N6OS2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
EGFR/CDK2-IN-4 is a dual inhibitor of EGFR and CDK-2, with IC50 values of 89.6 nM and 165.4 nM, respectively. It induces apoptosis in MCF-7 cells, arrests the cell cycle in S phase, and shows significant anticancer cytotoxicity, inhibiting MCF-7 cells with an IC50 of 2.74 μM[1]. It has a molecular formula of C24H16N6OS2 and a molecular weight of 468.55 g/mol.
Physical & Chemical Properties
| Molecular Formula | C24H16N6OS2 |
|---|---|
| Molecular Weight | 468.55 g/mol |
| SMILES | SC1=NN=C2SCC(C3=NN(C4=CC=CC=C4)C=C3C(C5=CC=C6C=CC=CC6=C5)=O)=NN21 |
| Signaling Pathway | JAK/STAT Signaling; Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: 89.6 (EGFR), 165.4 nM (CDK-2)[1]
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Salem M E, et al. Synthesis and Anti-Breast Cancer Potency of Mono-and Bis-(pyrazolyl [1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazine) Derivatives as EGFR/CDK-2 Target Inhibitors[J]. ACS Omega, 2023....
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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