| Field | Specification |
|---|---|
| Target | |
| Applications | |
| Molecular weight | |
| Molecular formula | C22H19N3O3 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
EGFR/HER2/DHFR-IN-3 is a potent dual inhibitor of EGFR and HER2, with IC50 values of 0.138 μM and 0.092 μM, respectively. It also inhibits DHFR, with an IC50 of 0.193 M. The compound arrests the cell cycle at S phase and induces apoptosis in MCF7 breast cancer cells[1]. It has a molecular formula of C22H19N3O3 and a molecular weight of 373.40 g/mol.
Physical & Chemical Properties
| Molecular Formula | C22H19N3O3 |
|---|---|
| Molecular Weight | 373.40 g/mol |
| SMILES | N#CC1=C(OCCC)N=C(C2=CC=C(C)C=C2)C=C1C3=CC=C([N+]([O-])=O)C=C3 |
| Target | EGFR, HER2, DHFR |
| Signaling Pathway | JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Metabolic Enzyme/Protease; Apoptosis |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
EGFR 0.138 μM (IC50) |
HER2 0.092 μM (IC50) |
DHFR 0.193 μM (IC50) |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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