| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C38H47BrFN10O2P |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
EGFR-IN-22 is a potent EGFR inhibitor with IC50 values of 4.91 nM against wild-type EGFR and 0.54 nM against EGFR L858R/T790M/C797S, as described in patent CN112538072A, compound 243[1]. It has the molecular formula C38H47BrFN10O2P and a molecular weight of 805.72 g/mol.
Physical & Chemical Properties
| CAS Number | 2634646-14-1 |
|---|---|
| Molecular Formula | C38H47BrFN10O2P |
| Molecular Weight | 805.72 g/mol |
| SMILES | O=P(C)(C)C1=C2N=CC=NC2=CC=C1NC3=NC(NC4=C(OC)C=C(N5CCC6(CCN(C(C)(CF)C)CC6)CC5)C(C7=CN(C)N=C7)=C4)=NC=C3Br |
| Target | EGFR L858R/T790M/C797S, EGFR (WT) |
| Signaling Pathway | JAK/STAT Signaling; Protein Tyrosine Kinase/RTK |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
EGFRL858R/T790M/C797S 0.54 nM (IC50) |
EGFR (WT) 4.91 nM (IC50) |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. EGFR-IN-22 is a potent EGFR inhibitor with IC50 of 4.91 nM and 0.54 nM for wild type EGFR and EGFRL858R/T790M/C797S, respectively (CN112538072A, compound 243)[1].
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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