| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C50H55ClFN5O5 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
EGFR-IN-43, identified as compound 17c, is a potent inhibitor of EGFR with single-digit nanomolar activity. It covalently links tamoxifen or endoxifen to the EGFR inhibitor gefitinib, retaining both ER antagonist activity and EGFR inhibition, and shows superior anti-cancer activity[1]. It has a molecular formula of C50H55ClFN5O5 and a molecular weight of 860.45 g/mol.
Physical & Chemical Properties
| CAS Number | 3031307-74-8 |
|---|---|
| Molecular Formula | C50H55ClFN5O5 |
| Molecular Weight | 860.45 g/mol |
| SMILES | ClC1=CC(NC2=C3C(C=C(OC)C(OCCCNC(CCCCCCN(CCOC4=CC=C(C=C4)/C(C5=CC=C(C=C5)O)=C(CC)\C6=CC=CC=C6)C)=O)=C3)=NC=N2)=CC=C1F |
| Signaling Pathway | JAK/STAT Signaling; Protein Tyrosine Kinase/RTK |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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