| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
EMD 527040 hydrochloride (CAS 2758431-92-2) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 2758431-92-2 |
|---|---|
| Molecular Formula | C29H33Cl3N4O5 |
| Molecular Weight | 623.96 g/mol |
| SMILES | O=C(CCCCNC1=CC=CC=N1)N(CH)(COCC2=CC=CC=C2)C(NC(C3=CC(Cl)=CC(Cl)=C3)CC(… |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
EMD 527040 hydrochloride is an effective integrin alphaVbeta6 inhibitor. The IC 50 values of EMD 527040 hydrochloride were 6 nM and 1.6 uM to inhibit alphaVbeta6 binding to fibronectin and alphaVbeta6 expression cells to fibronectin, respectively. EMD 527040 hydrochloride shows antifibrotic activity in animal models of biliary fibrosis and is active in vivo.
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
mg/mL (milligrams per milliliter) and mM (millimolar = millimoles per liter) are two concentration units for the same solution. To convert: mM = (mg/mL × 1000) / MW (g/mol). For example, for a compound with MW = 350 g/mol: 1 mg/mL = 1000/350 = 2.86 mM. Use the molar concentration calculator on the TargetMol website for quick conversions.
Yes — TargetMol inhibitors can be used in cell-based and in vitro experiments. Prepare a DMSO stock, then dilute into cell culture medium to the desired working concentration, keeping DMSO ≤ 0.1% (v/v) to avoid solvent toxicity. Note that not all compounds have published data for every cell line or assay system; in such cases, perform a dose-response experiment with appropriate positive and vehicle controls to validate efficacy in your specific model.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
