| Field | Specification |
|---|---|
| Alternative names | NSC624610 |
| CAS no. | |
| Applications | |
| Source | Plant — Leguminosae Cercis chinensis Bunge; Endogenous metabolite — Human Gut Microbiota Metabolites; Microbial |
| Molecular weight | |
| Molecular formula | C15H8O7 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Emodic acid, also known as NSC624610, is an anthraquinone compound isolated from A. microcarpus that can inhibit cancer cell proliferation by inhibiting NF-κB activity. It can also inhibit phosphorylation of p38, ERK and JNK, the secretion of the tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby suppressing the invasion and migration potential of cancer cells[1]. It is supplied as a brown to red solid (C15H8O7, MW 300.22) at 98.00% purity.
Physical & Chemical Properties
| CAS Number | 478-45-5 |
|---|---|
| Molecular Formula | C15H8O7 |
| Molecular Weight | 300.22 g/mol |
| Purity | 98.00% |
| Appearance | Solid |
| Color | Brown to red |
| Structure Classification | Quinones Anthraquinones |
| SMILES | OC1=CC(O)=CC(C(C2=C3C(O)=CC(C(O)=O)=C2)=O)=C1C3=O |
| Signaling Pathway | MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt; Protein Tyrosine Kinase/RTK; Metabolic Enzyme/Protease |
| Initial Source | Plant — Leguminosae Cercis chinensis Bunge; Endogenous metabolite — Human Gut Microbiota Metabolites; Microbial |
| Solubility | In Vitro: DMSO: 4 mg/mL (13.32 mM; Requires sonication and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | -20°C, protect from light, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 4 mg/mL (13.32 mM) | requires sonication and warming and heat to 60°C; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); protect from light, stored under nitrogen; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
In the murine mammary carcinoma 4T1, MDA-231, and MCF-7 lines, Emodic acid (0-100 μM, 72 h) shows strong antiproliferative activity, with IC50 values of 9.33, 8.56, 7.95 μM, respectively[1]. In the 4T1 cell line, Emodic acid (50 μM, 24 h) can significantly inhibit NF-κB transcriptional activity (by 80.75%), as well as p65 phosphorylation and MMP-9 mRNA expression[1]. Emodic acid (50 μM, 24 h) can inhibit secretion of the tumor-promoting cytokines IL-1β and IL-6 and expression of VEGF, thereby inhibiting invasion and migration of 4T1 cells[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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