| Field | Specification |
|---|---|
| Alternative names | Enramycin |
| CAS no. | |
| Applications | |
| Purity | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Enduracidin, also known as Enramycin, is a polypeptide antibiotic produced by the bacterium Streptomyces fungicides[1]. It is supplied as a light brown to brown solid at 4% purity.
Physical & Chemical Properties
| CAS Number | 11115-82-5 |
|---|---|
| Purity | 4% |
| Appearance | Solid |
| Color | Light brown to brown |
| Signaling Pathway | Anti-infection |
| Solubility | In Vitro: DMSO: < 1 mg/mL (insoluble or slightly soluble) |
| Storage | 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[3]. Matsuhashi M, et al. Inhibition of the Bacterial Cell Wall Synthesis in vitro by Enduracidin, a New Polypeptide Antibiotic. Agricultural and Biological Chemistry, 1969, 33(1): 134-137.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | < 1 mg/mL | insoluble or slightly soluble |
Data provided by the manufacturer.
In Vitro
Enduracidin shows antibacterial activity against multiple antibiotic-resistant Staphylococci strains[2]. Enduracidin blocks peptidoglycan synthesis in M. lysodeikticus, Staphylococcus aureus, and E. coli[3].
In Vivo
In a mouse model of intravenous Staphylococcus aureus infection, Enduracidin (s.c.; at 60 min post-infection) gives a 50% survival rate, with an ED50 of 2.27 mg/kg[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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