| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C23H22F3N5O3 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Ep300/CREBBP-IN-4 is a potent inhibitor of Ep300 and CREBBP with IC50 values of 0.024 and 0.064 μM, respectively, and it can be used in cancer research[1]. It has the molecular formula C23H22F3N5O3 (MW 473.45).
Physical & Chemical Properties
| CAS Number | 2259641-42-2 |
|---|---|
| Molecular Formula | C23H22F3N5O3 |
| Molecular Weight | 473.45 g/mol |
| SMILES | O=C(N1[C@H](C[C@H](C1)F)C(NC2=CC=C(NN=C3)C3=N2)=O)C4(C5=CC=C(C=C5)OC)CC(F)(C4)F |
| Target | EP300, CREBBP |
| Signaling Pathway | Epigenetics |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
EP300 0.024 μM (IC50) |
CREBBP 0.064 μM (IC50) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. NAITO Hiroyuki, et al. EP300 / CREBBP inhibitor. Patent JPWO2018235966A1.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Ep300/CREBBP-IN-4 inhibits intracellular H3K27Ac activity, with an IC50 of 0.020 μM[1]. At 38 nM-10 mM for 3 days, Ep300/CREBBP-IN-4 inhibits the growth of LK2 and TE-8 cells, with GI50s of 98.803 and 88.333 μM, respectively[1].
Cell Viability Assay[1]
| Cell Line | LK2 and TE-8 cells |
|---|---|
| Concentration | 38 nM-10 mM |
| Incubation Time | 3 days |
| Result | Inhibited LK2 and TE-8 cell growth with GI50s of 98.803 and 88.333 μM, respectively. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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