| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C12H10ClN7 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Epiblastin A is an ATP-competitive casein kinase 1 (CK1) inhibitor, with IC50 values of 8.9, 0.5, and 4.7 μM for CK1α, CK1δ, and CK1ε, respectively. It induces reprogramming of epiblast stem cells into embryonic stem cells through inhibition of CK1[1]. It is supplied as a light yellow to green yellow solid (C12H10ClN7, MW 287.71) at 99.44% purity.
Physical & Chemical Properties
| CAS Number | 16470-02-3 |
|---|---|
| Molecular Formula | C12H10ClN7 |
| Molecular Weight | 287.71 g/mol |
| Purity | 99.44% |
| Appearance | Solid |
| Color | Light yellow to green yellow |
| SMILES | NC1=NC(N)=C2N=C(C(N)=NC2=N1)C3=CC=CC(Cl)=C3 |
| Signaling Pathway | Cell Cycle/DNA Damage; Stem Cell/Wnt |
| Solubility | In Vitro: DMSO: 4.55 mg/mL (15.81 mM; Requires sonication and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 4.55 mg/mL (15.81 mM) | requires sonication and warming and heat to 60°C; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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