| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)-1-propen-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione, Patupilone |
| Cas No. | |
| Form | White Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 10 mM in DMSO |
| Source | Synthetic |
| Storage |
Epothilone B is a microtubule-stabilizing agent that promotes tubulin polymerization and inhibits cell division. In neuroscience, it is recognized for its neurotrophic properties, including the promotion of axonal regeneration and stabilization of microtubules in models of neurodegeneration. Epothilone B is being explored as a therapeutic candidate for diseases such as Alzheimer's, where microtubule destabilization contributes to neuronal dysfunction.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Epothilone B (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-238)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Julien B., Shah S. (2002) Antimicrob Agents Chemother. 46(9): 2772.
3. Balog D.M., et al. (1996) Angew Chem. 108: 2976. 4. J Ruchel et al. Science 2015, 348: 347-352
