| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C19H18BrN3O3S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
ERK-IN-6 is a potent anti-proliferative agent against esophageal squamous cell carcinoma (ESCC). It induces cell apoptosis via the ERK pathway and can be used in ESCC research[1]. Its molecular formula is C19H18BrN3O3S, with a molecular weight of 448.33 g/mol.
Physical & Chemical Properties
| Molecular Formula | C19H18BrN3O3S |
|---|---|
| Molecular Weight | 448.33 g/mol |
| SMILES | CC1(C)N/C(S/C1=C\C2=CC=C(Br)C=C2)=N/C3=CC=C(OC)C=C3[N+]([O-])=O |
| Signaling Pathway | Apoptosis |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: 16.8 μM (KYSE-30), 10.07 μM (KYSE-150), 13 μM (HET-1A), 202.2 μM (NES-G4T)[1]
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Marian NA, et al. Novel thiazolidines of potential anti-proliferation properties against esophageal squamous cell carcinoma via ERK pathway. European Journal of Medicinal Chemistry. 24 November 2022, 114909.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In ESCC cells, ERK-IN-6 (0-10 μM; 72 h) inhibits cell proliferation[1]. ERK-IN-6 (10 μM; 48-72 h) induces apoptosis through the ERK pathway[1].
Cell Proliferation Assay[1]
| Cell Line | KYSE-30, KYSE-150, HET-1A and NES-G4T cell lines |
|---|---|
| Concentration | 0-10 μM |
| Incubation Time | 72 hours |
| Result | Dose-dependently inhibited cell proliferation of KYSE-30, KYSE-150, HET-1A and NES-G4T cells with IC50 values of 16.8, 10.07, 13 and 202.2 μM, respectively. |
Apoptosis Analysis[1]
| Cell Line | KYSE-30 and KYSE-150 cell lines |
|---|---|
| Concentration | 10 μM |
| Incubation Time | 48 and 72 hours |
| Result | Induced KYSE-30 and KYSE-150 cell apoptosis with the loss of nuclei integrity at 72 h. |
Western Blot Analysis[1]
| Cell Line | KYSE-150 and NES-G4T cell lines |
|---|---|
| Concentration | 10 μM |
| Incubation Time | 4, 8 and 12 hours |
| Result | Time-dependently down regulated pERK. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
