| Field | Specification |
|---|---|
| Target | |
| Alternative names | ERK1, ERK2, ERT1, ERT2, MAP kinase 1, MAP kinase 2, MAPK1, MAPK2, MAPK3, p38, p40, p41, p41mapk, p42 MAPK, p44 ERK1, p44 MAPK, PRKM1, PRKM2, PRKM3 |
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| Immunogen | A 35 residue synthetic peptide, corresponding to Rat Erk1 MAP kinase with the CGG spacer group added and the peptide coupled to KLH. |
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Extracellular signal-regulated kinases 1 and 2 (Erk1/2) are central components of the MAPK signaling cascade, orchestrating cellular responses to growth factors, stress, and synaptic activity. In the nervous system, Erk1/2 regulate neuronal differentiation, synaptic plasticity, and memory formation. Dysregulation of Erk1/2 signaling has been implicated in the pathogenesis of multiple neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s disease.
Aberrant Erk1/2 activation can lead to chronic neuroinflammation, oxidative stress, and tau hyperphosphorylation—hallmarks of neurodegeneration. Conversely, controlled Erk1/2 signaling supports neuroprotection, axonal regeneration, and cognitive resilience. This dual role positions Erk1/2 as both a biomarker and a therapeutic target in neurodegenerative research.
As precision medicine advances, modulating Erk1/2 activity offers a promising strategy to restore neuronal function and delay disease progression.
A 1:1000 dilution of SPC-120 was sufficient for detection of ERK1/2 in 20 µg of HeLa cell lysate by ECL immunoblot analysis.
Cite this product varies by variant:
- SPC-120D — Size: 100 uL: Erk1/2 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-120D, RRID: AB_2266080)
- SPC-120D-A390 — Size: 100 uL: Erk1/2 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-120D-A390, RRID: AB_2703432)
- SPC-120D-A488 — Size: 100 uL: Erk1/2 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-120D-A488, RRID: AB_2703433)
- SPC-120D-A594 — Size: 100 uL: Erk1/2 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-120D-A594, RRID: AB_2703435)
- SPC-120D-APC — Size: 100 uL: Erk1/2 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-120D-APC, RRID: AB_2703441)
- SPC-120D-BI — Size: 100 uL: Erk1/2 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-120D-BI, RRID: AB_2703442)
- SPC-120D-FITC — Size: 100 uL: Erk1/2 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-120D-FITC, RRID: AB_2703443)
- SPC-120D-HRP — Size: 100 uL: Erk1/2 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-120D-HRP, RRID: AB_2703444)
- SPC-120D-PCP — Size: 100 uL: Erk1/2 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-120D-PCP, RRID: AB_2703446)
- SPC-120D-RPE — Size: 100 uL: Erk1/2 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-120D-RPE, RRID: AB_2703447)
- SPC-120S — Size: 12 uL: Erk1/2 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-120S, RRID: AB_2266080)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
2. Yoon S., and Seger R. (2006) Growth Factors 24:21-44.
3. Wolf G. (2005) Antioxid Redox Signal 7:1337-1345.
4. Chuerland D., Marmor G., Shainskaya A. and Seger R. (2008) J Biol Chem. Epub: http://www.jbc.org/cgi/doi/10.1074/jbc.M709030200
5. Zhuang S., and Schnellmann R.G. (2006) J Pharmacol Exp Ther 319:991-997.
