| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C31H32ClN7O3 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
ERK1/2 inhibitor 9 (Probe 1) is a covalent inhibitor of ERK1/2, showing sub-micromolar activity in cells (A375 GI50 = 0.47 μM) and causing downregulation of phospho-ERK1/2. When tagged with trans-cyclo-octene (TCO), it can react with Tz-Thalidomide (tetrazine-tagged Thalidomide) to form the corresponding ERK-CLIPTAC, eliciting degradation of ERK1/2[1]. It is supplied as an off-white to light yellow solid (C31H32ClN7O3, MW 586.08) at 95.91% purity.
Physical & Chemical Properties
| CAS Number | 2169302-75-2 |
|---|---|
| Molecular Formula | C31H32ClN7O3 |
| Molecular Weight | 586.08 g/mol |
| Purity | 95.91% |
| Appearance | Solid |
| Color | Off-white to light yellow |
| SMILES | O=C(NCCC#CC1=NC=CC(NC2=NC=C(C(NC3=C(NC(C=C)=O)C=CC=C3)=N2)Cl)=C1)OC4CC/C=C\CCC4 |
| Target | ERK1, ERK2 |
| Signaling Pathway | MAPK/ERK Pathway; Stem Cell/Wnt |
| Solubility | In Vitro: DMSO: 50 mg/mL (85.31 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | -20°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 50 mg/mL (85.31 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); protect from light; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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