| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C22H25N5O5S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
ET receptor antagonist 2 is an orally active ET receptor antagonist with an IC50 of 0.22 nM, which can be used in research on pulmonary arterial hypertension (PAH). It attenuates monocrotaline-induced PAH in a rat model[1]. It has the molecular formula C22H25N5O5S and a molecular weight of 471.53 g/mol.
Physical & Chemical Properties
| Molecular Formula | C22H25N5O5S |
|---|---|
| Molecular Weight | 471.53 g/mol |
| SMILES | CS(=O)(NC1=NC(C2=NC=CC=N2)=NC(OCC/C=C/CC)=C1OC3=CC=CC=C3OC)=O |
| Signaling Pathway | Vitamin D Related/Nuclear Receptor |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: 0.22 nM (ET receptor)[1]
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vivo
ET receptor antagonist 2, given po at 150 mg/kg/d or 300 mg/kg/d starting 48 h following MCT administration and continued for 21-26 d, significantly reduces mPAP and lowers the levels of HIF1α, ANP, and TNNI3 in MCT-exposed rats. It also shows an antioxidant profile and inhibits lipid peroxidation[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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