| Field | Specification |
|---|---|
| Alternative names | Trimethylopropane phosphate |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C6H11O4P |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Etbicyphat, also known as Trimethylopropane phosphate, is a potent competitive antagonist of GABA(A) receptors. It induces epileptiform activity in hippocampal CA1 neurons and binds to the GABA(A)-benzodiazepine receptor site[1]. It is supplied as an off-white to light yellow solid (C6H11O4P, MW 178.12) at 98.0% purity.
Physical & Chemical Properties
| CAS Number | 1005-93-2 |
|---|---|
| Molecular Formula | C6H11O4P |
| Molecular Weight | 178.12 g/mol |
| Purity | 98.0% |
| Appearance | Solid |
| Color | Off-white to light yellow |
| SMILES | CCC(CO1)(CO2)CO[P]12=O |
| Signaling Pathway | Membrane Transporter/Ion Channel; Neuronal Signaling |
| Solubility | In Vitro: DMSO: ≥ 100 mg/mL (561.42 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) * "≥" means soluble, but saturation unknown. |
| Storage | 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | ≥ 100 mg/mL (561.42 mM) | use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); protect from light; avoid repeated freeze-thaw cycles.
In Vivo
Choose the formulation that suits the animal model and route of administration; percentages are volume ratios of the final working solution. Start from a clear DMSO stock (see In Vitro above), add the co-solvents one at a time in the order listed, mixing after each addition, and prepare the working solution fresh on the day of dosing. If precipitation or phase separation occurs, gentle warming or sonication can help.
Protocol 1
| Composition | 10% DMSO + 90% (20% SBE-β-CD in saline) |
|---|---|
| Result | ≥ 2.5 mg/mL (14.04 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 900 μL 20% SBE-β-CD in saline. 20% SBE-β-CD in saline: dissolve 2 g SBE-β-CD powder in 10 mL saline until clear (4°C, store up to one week). |
Protocol 2
| Composition | 10% DMSO + 90% Corn Oil |
|---|---|
| Result | ≥ 2.5 mg/mL (14.04 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). Use with caution if continuous dosing will exceed two weeks. For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 900 μL corn oil. |
Data provided by the manufacturer.
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