| Field | Specification |
|---|---|
| Alternative names | (5S,5aR,8aR,9R)-9-(4-Hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-β-D-glucopyranoside |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C29H32O13 |
| Purity | |
| Bioactivity | Inducer |
| Activity | |
| Solubility | Soluble to 100 mM in DMSO |
| SMILES | |
| InChIKey | |
| Form | White solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Etoposide is a topoisomerase II inhibitor that induces DNA strand breaks by preventing the re-ligation of cleaved DNA. This mechanism leads to apoptosis, making etoposide a useful tool in studying DNA damage pathways in neurons. It is also used in models of neurotoxicity and to investigate the role of DNA repair in neurodegenerative conditions.
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S53 - Avoid exposure - obtain special instruction before use
Risk Phrases:
- R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed
- R45 - May cause cancer
- R62 - Possible risk of impaired fertility
- R68 - Possible risk of irreversible effects
Hazard Phrases:
H302-H350
Precautionary Phrases:
P201-P308 + P313
Etoposide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-244)
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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