| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | ETP46464 |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
ETP-46464 (CAS 1345675-02-6) is a research-grade small molecule supplied by TargetMol.
Alternative names: ETP46464
Physical Properties
| CAS Number | 1345675-02-6 |
|---|---|
| Molecular Formula | C30H22N4O2 |
| Molecular Weight | 470.52 g/mol |
| SMILES | O=C1N(C2=C3C(=NC=C2CO1)C=CC(=C3)C4=CC5=C(N=C4)C=CC=C5)C6=CC=C(C(CN)(C)… |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
Target(s): ATM/ATR, PI3K, DNA-PK, mTOR
Signaling pathway(s): DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
It is not recommended to store DMSO stock solutions at room temperature. Once the stock solution is prepared, aliquot into single-use volumes and store at −20 °C (or −80 °C for sensitive compounds). Room-temperature storage accelerates chemical degradation and moisture uptake. When ready to use, thaw an aliquot at room temperature, use immediately, and avoid repeated freeze-thaw cycles.
For small packages(1 mg, 5 mg, 10 mg, etc.）, it is not recommended to weigh them again which may lead to compound loss and inaccurate measurement. Our products are imported in their original packaging and accurately weighed, so you can directly dissolve the compound in the appropriate solvent upon receipt. For large packages, you can weigh and prepare stock solutions. It is recommended to start with at least 10 mg to reduce error. If conditions permit, you can first prepare a high-concentration stock solution and then aliquot it for use
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
