| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Source | Plant — Oleaceae Syringa pubescens subsp. patula (Palib.) M. C. Chang & X. L. Chen |
| Molecular weight | |
| Molecular formula | C27H34O12 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Eucommin A is a natural polyphenolic antioxidant that forms stable complexes with EGFR and MAPK8 through hydrogen bonding and hydrophobic interactions, and it regulates osteoarthritis-related autophagy; it is applicable to research on oxidative stress, including osteoarthritis[1][2].
It has the molecular formula C27H34O12 and a molecular weight of 550.56 g/mol.
Physical & Chemical Properties
| CAS Number | 99633-12-2 |
|---|---|
| Molecular Formula | C27H34O12 |
| Molecular Weight | 550.56 g/mol |
| Structure Classification | Phenylpropanoids Lignans |
| SMILES | O(C)C=1C=C([C@@H]2[C@@]3([C@@]([C@H](OC3)C4=CC(OC)=C(O)C=C4)(CO2)[H])[H])C=C(OC)C1O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O |
| Signaling Pathway | JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; MAPK/ERK Pathway; Autophagy |
| Initial Source | Plant — Oleaceae Syringa pubescens subsp. patula (Palib.) M. C. Chang & X. L. Chen |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Eucommin A forms multiple hydrogen bonds with purified human EGFR protein and human MAPK8 protein and binds both tightly, with binding energies of -7.8 kcal/mol and -9.1 kcal/mol, respectively[1]. Eucommin A is a polyphenolic component that shows antioxidant activity in vitro[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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