| Field | Specification |
|---|---|
| Alternative names | Haplophytin B; Haplophytine B |
| CAS no. | |
| Applications | |
| Source | Plant — Rutaceae Haplophyllum acutifolium (DC.) G. Don |
| Molecular weight | |
| Molecular formula | C18H21NO6 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Evoxine, also known as Haplophytin B and Haplophytine B, selectively inhibits CO2-induced immunosuppression and suppresses expression of interleukin-6 and the chemokine CCL2 in human THP-1 macrophages. It also shows antimicrobial activity against a wide range of bacteria, performing especially well in minimum inhibitory concentration (MIC) tests against Escherichia coli, Bacillus subtilis and Staphylococcus aureus, and its extracts may be applicable to crude drug preparations in West Africa provided in vivo toxicity results are negative[1].
It has the molecular formula C18H21NO6 and a molecular weight of 347.36 g/mol.
Physical & Chemical Properties
| CAS Number | 522-11-2 |
|---|---|
| Molecular Formula | C18H21NO6 |
| Molecular Weight | 347.36 g/mol |
| Structure Classification | Alkaloids Other Alkaloids |
| SMILES | COC1=C2C(C(OC)=C3C(OC=C3)=N2)=CC=C1OC[C@@H](O)C(C)(O)C |
| Signaling Pathway | Anti-infection |
| Initial Source | Plant — Rutaceae Haplophyllum acutifolium (DC.) G. Don |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae)
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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