| Field | Specification |
|---|---|
| Alternative names | 5-Formamidoimidazole-4-carboxamide ribotide |
| CAS no. | |
| Applications | |
| Source | Microbial — Methanocaldococcus jannaschii |
| Molecular weight | |
| Molecular formula | C10H15N4O9P |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
FAICAR, also known as 5-formamidoimidazole-4-carboxamide ribotide, is a purine nucleotide and the IMP cyclohydrolase substrate of Cryptococcus neoformans ATIC, serving as a key intermediate in the de novo purine synthesis pathway. It can be used in studies related to Cryptococcus neoformans infection[1][2][3]. It is supplied as a dark purple to black solid (C10H15N4O9P, MW 366.22) at 85.0% purity.
Physical & Chemical Properties
| CAS Number | 13018-54-7 |
|---|---|
| Molecular Formula | C10H15N4O9P |
| Molecular Weight | 366.22 g/mol |
| Purity | 85.0% |
| Appearance | Solid |
| Color | Dark purple to black |
| Structure Classification | Ketones, Aldehydes, Acids |
| SMILES | O=C(C1=C(NC=O)N([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)C=N1)N |
| Signaling Pathway | Cell Cycle/DNA Damage |
| Initial Source | Microbial — Methanocaldococcus jannaschii |
| Storage | -20°C, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
Using FAICAR (0.005-0.3 mM) as substrate at 37°C, recombinantly expressed C. neoformans ATIC shows IMP cyclohydrolase activity with a Km_app of 30 μM, a Vmax of 8.6 U/mg, and a kcat of 7.7 s−1[1]. FAICAR (0.1-4 μM) serves as a substrate for the IMP cyclohydrolase domain of human AICAR transformylase-IMP cyclohydrolase and has a Ks of 0.87 μM at pH 7.4 and supports IMP cyclohydrolase specific activity of 29.5 nmol IMP formed/min/μg protein at 4 μM[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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