| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C36H49N9O8 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
FAPI-74 is a PET (positron emission tomography) tracer that targets the fibroblast activation protein (FAP). It can be used for research on FAP-positive tumors[1][2]. It is supplied as an off-white to light yellow solid (C36H49N9O8, MW 735.83) at 99.82% purity.
Physical & Chemical Properties
| CAS Number | 2374782-76-8 |
|---|---|
| Molecular Formula | C36H49N9O8 |
| Molecular Weight | 735.83 g/mol |
| Purity | 99.82% |
| Appearance | Solid |
| Color | Off-white to light yellow |
| SMILES | O=C(C1=CC=NC(C=C2)=C1C=C2OCCCN(CC3)CCN3C(CN(CCN4CC(O)=O)CCN(CC4)CC(O)=O)=O)NCC(N(CCC5)[C@@H]5C#N)=O |
| Signaling Pathway | Immunology/Inflammation |
| Solubility | In Vitro: DMSO: 125 mg/mL (169.88 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Uwe Haberkorn, et al. Fap inhibitor. Patent, WO2019154886A1.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 125 mg/mL (169.88 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
Chelation with 18F-AlF[2] Trapping of 2-10 GBq 18F fluoride in 4 mL water was done on an anion exchange cartridge, followed by elution with 0.30 mL 0.5 M NaOAc pH 3.9. Following incubation of the solution for 5 min at room temperature with 6 μL of AlCl3 in water (10 mM) and 300 μL dimethyl sulfoxide, 20 μL of a FAPI-74 solution (4 mM) was added. The reaction proceeded at 95 °C for 15 min; afterward it was cooled to room temperature, diluted with 5 mL water, and worked up by SPE. Elution of the final product used 0.5 mL ethanol and 5 mL 0.9% saline, and phosphate buffer was spiked in before sterile filtration. For chelation with 68Ga, 1.00 mL 68Ge/68Ga-generator eluate (0.6 M hydrochloric acid; ca. 1.2 GBq) was added to a mixture made up of 15 μL FAPI-74 solution (4 mM in water) together with 310 μL sodium acetate (2.5 M in water) plus 0.50 mL ethanol. PET/CT imaging for tumor volume delineation to guide radiotherapy in lung cancer[3] PANC-1 xenograft mice (9 weeks old, body weight=25.3±1.2 g, n=9) underwent PET imaging on a small animal PET scanner 3 weeks after implantation. Under 2% isoflurane anesthesia, [18F]FAPI-74 (12.4±1.7 MBq) was injected into the tail vein. The bolus injection and the start of the dynamic PET scans (scan duration=70 min, n=2) were simultaneous. Static PET scans (n=7, scan duration=10 min) were acquired 1 h after injection, and a CT scan followed.
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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