| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C27H21ClN6O8S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
FD2157 is a photosensitive PI3K inhibitor, with IC50 values of 43 nM, 83 nM, 84 nM, and 14 nM against PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively. Upon exposure to 365 nm UV light, it potently inhibits cancer cell proliferation and induces cell apoptosis[1]. It has a molecular formula of C27H21ClN6O8S and a molecular weight of 625.01 g/mol.
Physical & Chemical Properties
| CAS Number | 3046403-79-3 |
|---|---|
| Molecular Formula | C27H21ClN6O8S |
| Molecular Weight | 625.01 g/mol |
| SMILES | O=C(OCC1=CC(OC)=C(OC)C=C1[N+]([O-])=O)N(N=C2)C(C2=C3)=NC=C3C4=CN=C(Cl)C(NS(=O)(C5=CC=CC=C5)=O)=C4 |
| Signaling Pathway | PI3K/Akt/mTOR; Apoptosis |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
Activity & Target
43 nM, 83 nM, 84 nM, 14 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ[1]
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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