| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C16H14N2O6S |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
FEN1-IN-7 is a selective inhibitor of Flap endonuclease-1 (FEN1, IC50 = 18 nM), which functions in mammalian cells to repair DNA damage. It also targets the related endonuclease xeroderma pigmentosum G (XPG), with an IC50 value of 3.04 μM, and it increases the sensitivity of cancer cells to DNA alkylating or methylating agents[1]. It is supplied as a white to off-white solid (C16H14N2O6S, MW 362.36) at 99.93% purity.
Physical & Chemical Properties
| CAS Number | 824983-90-6 |
|---|---|
| Molecular Formula | C16H14N2O6S |
| Molecular Weight | 362.36 g/mol |
| Purity | 99.93% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=C1C2=C(N(CC3=CC(OC)=C4OCOC4=C3)C(N1O)=O)SC=C2C |
| Signaling Pathway | Immunology/Inflammation |
| Solubility | In Vitro: DMSO: 50 mg/mL (137.98 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, sealed storage, away from moisture and light. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 50 mg/mL (137.98 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture and light; avoid repeated freeze-thaw cycles.
In Vivo
Choose the formulation that suits the animal model and route of administration; percentages are volume ratios of the final working solution. Start from a clear DMSO stock (see In Vitro above), add the co-solvents one at a time in the order listed, mixing after each addition, and prepare the working solution fresh on the day of dosing. If precipitation or phase separation occurs, gentle warming or sonication can help.
Protocol 1
| Composition | 10% DMSO + 90% Corn Oil |
|---|---|
| Result | 2.5 mg/mL (6.90 mM); suspension; requires sonication |
| How to prepare | Gives a suspension at 2.5 mg/mL. The suspension is suitable for oral and intraperitoneal dosing. For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 900 μL corn oil. |
Data provided by the manufacturer.
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