| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Filipin, FILIPIN III, (17E,19E,21E,23E,25E)-4,6,8,10,12,14,16,27-octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one, Filimirasin, Desoxylagosin |
| Cas No. | |
| Form | White or slightly yellow powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in methanol (10 mg/mL), ethanol (2 mg/mL) or DMSO (3 mg/mL) |
| Source | From Streptomyces filipinensis |
| Storage |
Filipin III is a polyene macrolide that binds to unesterified cholesterol, disrupting membrane microdomains and lipid rafts. In neurodegenerative disease research, Filipin III is commonly used as a fluorescent probe to visualize cholesterol accumulation, particularly in Niemann-Pick type C disease. Its role in studying cholesterol trafficking and lysosomal storage disorders makes it a critical reagent in neuroscience and cellular pathology.
WHMIS Classification: D2B Toxic Material Causing Other Toxic Effects Moderate skin irritant
Moderate respiratory irritant
Moderate eye irritant
GHS Classification: Skin irritation (Category 2)
Eye irritation (Category 2A)
Specific target organ toxicity - single exposure (Category 3)
Signal word:
Warning
Hazard statement(s):
- H315 Causes skin irritation.
- H319 Causes serious eye irritation.
- H335 May cause respiratory irritation.
Precautionary statement(s):
- P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
- P264 Wash skin thoroughly after handling.
- P271 Use only outdoors or in a well-ventilated area.
- P280 Wear protective gloves/ eye protection/ face protection.
- P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
- P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
- P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P312 Call a POISON CENTER/doctor if you feel unwell.
- P321 Specific treatment (see supplemental first aid instructions on this label).
- P332 + P313 If skin irritation occurs: Get medical advice/ attention.
- P337 + P313 If eye irritation persists: Get medical advice/ attention.
- P362 Take off contaminated clothing and wash before reuse.
- P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
- P405 Store locked up.
- P501 Dispose of contents/ container to an approved waste disposal plant.
Filipin III (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-551)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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