| Field | Specification |
|---|---|
| Alternative names | 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol,hydrochloride; Fingolimod |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C19H34ClNO2 |
| Purity | |
| Bioactivity | Agonist |
| Activity | |
| Solubility | Soluble to 100 mg/ml in DMSO or to 40 mg/ml in ethanol (warmed) |
| SMILES | |
| InChIKey | |
| Form | White solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
FTY720 Hydrochloride, also known as fingolimod, is a potent modulator of sphingosine 1-phosphate (S1P) receptors. Upon phosphorylation by sphingosine kinase, it binds to S1P receptors, sequestering lymphocytes in lymph nodes and reducing neuroinflammation. This mechanism underpins its clinical use in multiple sclerosis. In neuroscience, FTY720 has demonstrated the ability to stimulate neuronal gene expression, promote axonal growth, and support regeneration. Recent studies also highlight its potential to reduce α-synuclein pathology in Parkinson’s disease models, making it a promising candidate for neurodegenerative disease research.
Classification: D2B Toxic Material Causing Other Toxic Effects
Moderate skin irritant
Moderate eye irritant
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statement(s):
- H315 Causes skin irritation.
- H319 Causes serious eye irritation.
- H335 May cause respiratory irritation.
- H412 Harmful to aquatic life with long lasting effects.
Precautionary statement(s):
- P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
- P273 Avoid release to the environment.
- P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Fingolimod (FTY720 Hydrochloride) (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-523)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Brinkmann V., et al. (2002) J Biol Chem. 277(24): 21453-7. 3. Anastasiadou S., and Knoll B. (2016) Exp. Neurol. 279: 243-260. 4. Vidal-Martinez G., at al. (2019) Neuroscience. 411: 1-10.
