| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 3-(3-Pyridinyl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)prolinate, Tacrolimus, Fujimycin |
| Cas No. | |
| Form | White powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (50 mg/mL) or ethanol (50mg/mL) |
| Source | Synthetic |
| Storage |
FK506, also known as Tacrolimus or Fujimycin, is a macrolide immunosuppressant with emerging neuroprotective properties. It inhibits calcineurin by forming a complex with FKBP12, thereby preventing NF-AT dephosphorylation and downstream T-cell activation. In neuroscience, FK506 has shown promise in protecting neurons from degeneration in models of antiretroviral toxic neuropathy and other neuroinflammatory conditions. Its ability to modulate calcium signaling and reduce neuroinflammation positions it as a potential therapeutic agent for neurodegenerative diseases.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H301
Precautionary Phrases:
P301 + P310
FK506 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-214)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Ganong W.F., Review of Medical Physiology (22nd ed.) Lange Medical Books. P.530
3. Liu J. Lane W., Friedman J, Weissman I and Schreiber S. (1991) Cell. 66(4): 807-815 4. Keswani S., et al. (2003) Ann Neurol. 53(1): 57-64.
