| Field | Specification |
|---|---|
| Target | |
| Alternative names | FK506 binding protein 4, FKBP4, FKBP59, HBI, HSP56, p52, p59, PPIase, Rotamase, T cell FK506 binding protein |
| Accession number | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | Recombinant full-length human FKBP52 protein |
| Purification | |
| Cellular localization | |
| Concentration | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
FKBP52 (FK506-binding protein 4) is a co-chaperone that interacts with Hsp90 and steroid hormone receptors, influencing protein trafficking, microtubule dynamics, and neuronal signaling. In the nervous system, FKBP52 plays a protective role by regulating tau protein conformation and preventing its pathological aggregation.
Reduced FKBP52 levels have been linked to increased tau pathology in Alzheimer’s disease, suggesting a neuroprotective function. FKBP52 also modulates axonal transport and synaptic stability, processes that are disrupted in several neurodegenerative conditions.
As a regulator of both protein homeostasis and cytoskeletal integrity, FKBP52 represents a promising therapeutic target for halting or reversing neurodegenerative processes.
0.5 µg/ml was sufficient for detection of FKBP52 in 20 µg total protein using WB by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary.
Cite this product varies by variant:
- SMC-139D — Size: 100 ug: FKBP52 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-139D, RRID: AB_2293934)
- SMC-139D-A390 — Size: 100 ug: FKBP52 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-139D-A390, RRID: AB_2698279)
- SMC-139D-A488 — Size: 100 ug: FKBP52 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-139D-A488, RRID: AB_2698280)
- SMC-139D-A594 — Size: 100 ug: FKBP52 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-139D-A594, RRID: AB_2698282)
- SMC-139D-APC — Size: 100 ug: FKBP52 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-139D-APC, RRID: AB_2698288)
- SMC-139D-BI — Size: 100 ug: FKBP52 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-139D-BI, RRID: AB_2698289)
- SMC-139D-FITC — Size: 100 ug: FKBP52 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-139D-FITC, RRID: AB_2698290)
- SMC-139D-HRP — Size: 100 ug: FKBP52 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-139D-HRP, RRID: AB_2698291)
- SMC-139D-PCP — Size: 100 ug: FKBP52 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-139D-PCP, RRID: AB_2698293)
- SMC-139D-RPE — Size: 100 ug: FKBP52 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-139D-RPE, RRID: AB_2698294)
- SMC-139S — Size: 12 ug: FKBP52 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-139S, RRID: AB_2293934)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
2. Davies T.H., Ning Y.N., and Sanchez E.R. (2002) J Biol. Chem. 277 (7): 4597-4600.
3. Wu, B. et al. (2004) Proc. Natl. Acad. Sci. USA. 101(22): 8348-8353.
4. Denny W.B., Prapapanich V., Smith D.F., and Scammell J.G. (2005) Endocrinology 146(7):3194-3201.
5. Cox M.B. et al. (2007) Molecular Endocrinology. Epub.
