| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C27H37N9O8 |
| Purity | |
| Activity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Folate-PEG3-amine is a cleavable, three-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. It is supplied as a light yellow to yellow solid (C27H37N9O8, MW 615.64) at 99.69% purity.
Physical & Chemical Properties
| CAS Number | 710323-40-3 |
|---|---|
| Molecular Formula | C27H37N9O8 |
| Molecular Weight | 615.64 g/mol |
| Purity | 99.69% |
| Appearance | Solid |
| Color | Light yellow to yellow |
| SMILES | O=C(O)[C@@H](NC(C1=CC=C(NCC2=CN=C3NC(N)=NC(C3=N2)=O)C=C1)=O)CCC(NCCOCCOCCOCCN)=O |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related |
| Bioactivity Class | Cleavable Linker |
| Solubility | In Vitro: DMSO: ≥ 100 mg/mL (162.43 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) * "≥" means soluble, but saturation unknown. |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | ≥ 100 mg/mL (162.43 mM) | use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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