| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C9H14N4O7S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
FPI-1523, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kd values of 4 nM against CTX-M-15 and 34 nM against OXA-48. It also inhibits PBP2, with an IC50 of 3.2 μM, and exhibits considerable antimicrobial activity[1]. The compound has the molecular formula C9H14N4O7S and a molecular weight of 322.30 g/mol.
Physical & Chemical Properties
| CAS Number | 1452459-50-5 |
|---|---|
| Molecular Formula | C9H14N4O7S |
| Molecular Weight | 322.30 g/mol |
| SMILES | CC(NNC([C@H]1[N@@]2C(N([C@H](CC1)C2)OS(=O)(O)=O)=O)=O)=O |
| Signaling Pathway | Anti-infection |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
FPI-1523 inhibits E. coli K12 and PBP2, with a MIC of 4 μg/mL and an IC50 of 0.4 μg/mL, respectively[1]. It also inhibits E. coli BW25113 pGDP-2 transformants carrying either an empty vector or a vector expressing different β-lactamases, with low MICs (1-2 μM)[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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FPI-1523, a novel β-lactamase inhibitor, enhances imipenem activity against carbapenemase-producing Enterobacterales. J Glob Antimicrob Resist 2026 Jul 8:50:195-203. PMID: 42419642
