| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C27H28BrN3O2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
FtsZ-IN-8 acts as a potent FtsZ inhibitor, promoting FtsZ polymerization while suppressing its GTPase activity, which disrupts bacterial cell division and leads to bacterial cell death. The compound displays bactericidal activity with rapid killing and little apparent tendency to select for bacterial resistance. It also shows low hemolytic activity and low cytotoxicity toward mammalian cells[1]. It has the molecular formula C27H28BrN3O2 and a molecular weight of 506.43 g/mol.
Physical & Chemical Properties
| Molecular Formula | C27H28BrN3O2 |
|---|---|
| Molecular Weight | 506.43 g/mol |
| SMILES | CCCCCCCCNC(C1=CC2=C(NC3=C2C=C[N+]4=C3C(C5=C4C=CC=C5)=O)C=C1)=O.[Br-] |
| Signaling Pathway | Anti-infection |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Among the tested Gram-positive bacteria, FtsZ-IN-8 inhibits S. aureus (MRSA), the methicillin-resistant strain (MIC=0.098 μg/mL), B. subtilis (MIC=0.098 μg/mL), and S. pneumoniae (MIC=0.39 μg/mL)[1]. Bacterial growth is suppressed by FtsZ-IN-8 (1-4× MIC; 0-24 h). Additionally, FtsZ-IN-8 (4× MIC; 4 h) disrupts the surface of MRSA ATCC43300 cells, with notable wrinkling and filamentation[1]. FtsZ-IN-8 (4 μg/mL; 10 min; 25 °C) promotes FtsZ polymerization, and at 0.02-0.64 μg/mL (30 min) it inhibits FtsZ GTPase activity in a dose-dependent manner[1]. FtsZ-IN-8 (12.5 μg/mL; 1 h; 37 °C) shows negligible hemolytic activity against human erythrocytes RAW264.7 cells[1].
Cell Viability Assay[1]
| Cell Line | MRSA ATCC43300 |
|---|---|
| Concentration | 1 ×, 2 ×, 4 × MIC; MIC=0.098 μg/mL |
| Incubation Time | 0 h, 0.5 h, 1 h, 1.5 h, 2 h, 4 h, 6 h, 8 h, 12 h, 22 h, and 24 h |
| Result | Inhibited the growth of bacteria, and more fast compared with Vancomycin. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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