| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Source | Microbial — Aspergillus fumigatus |
| Molecular weight | |
| Molecular formula | C24H23N5O4 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Fumiquinazoline A is a peptidyl quinazolinone indole alkaloid with antifungal activity, isolated from Aspergillus fumigatus. It acts as a substrate of the FAD-dependent amide oxidase Af12070, a flavoenzyme that oxidizes it to the seven-membered spiroaminal Fumiquinazoline C, and it is used in studies of fungal infections[1][2][3].
It has the molecular formula C24H23N5O4 and a molecular weight of 445.47 g/mol.
Physical & Chemical Properties
| CAS Number | 140715-85-1 |
|---|---|
| Molecular Formula | C24H23N5O4 |
| Molecular Weight | 445.47 g/mol |
| Structure Classification | Alkaloids Indole Alkaloids |
| SMILES | O[C@@]1([C@]2([H])N(C([C@@H](N2)C)=O)C3=CC=CC=C31)C[C@H]4N5C([C@@H](NC4=O)C)=NC6=CC=CC=C6C5=O |
| Signaling Pathway | Metabolic Enzyme/Protease; Anti-infection |
| Initial Source | Microbial — Aspergillus fumigatus |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Fumiquinazoline A is a substrate of the FAD-dependent oxidase Af12070 Δ1-24, which drives O2 consumption at an apparent turnover number of 4.6 min-1[1]. Af12070 Δ1-24 oxidizes Fumiquinazoline A (200 μM; 0.1-20 hrs) to the seven-membered spiroaminal Fumiquinazoline C[1]. Fumiquinazoline A shows moderate antifungal activity versus phytopathogenic fungi, with MIC values of 12.5-25 μg/mL, and is more active than Fumiquinazoline D[3].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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