| Field | Specification |
|---|---|
| Alternative names | Camboginol, 3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-bicyclo[3.3.1]non-3-ene-2,9-dione |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C38H50O6 |
| Purity | |
| Bioactivity | Inhibitor |
| Activity | |
| Solubility | Soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol |
| SMILES | |
| InChIKey | |
| Form | Yellow solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Garcinol is a natural, cell-permeable inhibitor of histone acetyltransferases p300 and pCAF (IC₅₀ = 7 µM and 5 µM, respectively). It induces apoptosis, promotes hematopoietic stem cell expansion, and exhibits anti-inflammatory properties.
In neuroscience, Garcinol has been shown to promote neurogenesis in cortical progenitor cells and suppress neuroinflammation in Alzheimer’s models by modulating NF-κB signaling. Its ability to regulate histone acetylation and transcriptional activity positions it as a promising compound for exploring epigenetic therapies in neurodegenerative diseases.
Classification: Caution- Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
Garcinol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-355)
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2. Parasramka M.A., et al. (2011) Nutr. Cancer. 63: 456.
3. Nishino T., et al. (2011) Nutr. PLoS One 6: e24298.
