| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Soluble in DMSO, DMF and other organic solvents. Centrifuge all products before handling (10000 x g 5 min). |
| Source | Natural |
| Storage | |
| Target |
Product details
- Chemical name: (4R)-4-[(2E)-3-carboxy-3-methylprop-2-en-1-yl]-14-hydroxy-6,6,18-trimethyl-21-(3-methylbut-2-en-1-yl)-18-(4-methylpent-3-en-1-yl)-12-oxo-2,5,19-trioxapentacyclo[11.8.0.0^{3,7}.0^{3,11}.0^{15,20}]henicosa-1(21),10,13,15(20),16-pentaene-4-carboxylic acid
- Also known as: CHEMBL1456870
- PubChem CID: 6857794
- Molecular formula: C38H46O9.
- Purity: >95%
- Concentration: 10-100 µM.
- Form: Lyophilized Powder
- Solubility: Soluble in DMSO, DMF and other organic solvents. Centrifuge all products before handling (10000 x g 5 min).
- Reconstitution: Soluble in DMSO, DMF and other organic solvents. Centrifuge all products before handling (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: P2X7 receptors
- Source: Natural
- Activity: Garcinolic acid is a natural compound isolated from Garcinia resin, shown to facilitate and potentiate cellular responses mediated by the purinergic P2X7 receptors at over 10 µM1.
- Alternative names: CHEMBL1456870
Scientific background
Garcinolic acid, a type of xanthone, is a positive modulator of the purinergic P2X7 receptors. It facilitates and potentiates cellular responses mediated by the purinergic P2X7 receptors at concentrations over 10 µM1,2.P2X receptors are ligand-gated cation-permeable channel complexes that are activated by extracellular ATP. This family contains seven subtypes: P2X1-P2X7 that can be assembled as trimeric complexes. P2X7 receptors participate in a variety of cellular responses such as membrane permeabilization, activation of caspases, cytokine release, cell proliferation, and apoptosis. P2X7 receptors are expressed in almost all tissues, particularly in cells of haematopoietic origin1,3.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
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