| Field | Specification |
|---|---|
| Alternative names | 2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl) maleimide, 3-(N-[Dimethylamino]propyl-3-indolyl)-4-(3-indolyl)maleimide, 3-[1-[3-(Dimethylamino)propyl]1H-indol-3-yl]-4-(1Hindol-3-yl)1H-pyrrole-2,5dione, Bisindolylmaleimide I |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C25H24N4O2 |
| Purity | |
| Bioactivity | Inhibitor |
| Activity | |
| Solubility | Soluble in dimethyl formamide or DMSO (10 mg/ml, warm to 40°C and vortex well) |
| SMILES | |
| InChIKey | |
| Form | Red solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
GF109203X is a potent and selective inhibitor of protein kinase C (PKC), particularly the α and β1 isoforms. It also inhibits glycogen synthase kinase-3 (GSK-3) and exhibits anti-inflammatory effects. In neuroscience, GF109203X is used to study PKC and GSK-3 signaling in neuronal plasticity, neuroinflammation, and autophagy. Its ability to modulate kinase activity and telomerase function makes it a useful tool for investigating neurodegenerative processes and potential therapeutic interventions targeting kinase dysregulation.
Classification: Acute toxicity, Oral (Category 4), H302
Carcinogenicity (Category 2), H351
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
- H302 Harmful if swallowed.
- H351 Suspected of causing cancer.
Precautionary statements:
- P201 Obtain special instructions before use.
- P202 Do not handle until all safety precautions have been read and understood.
- P264 Wash skin thoroughly after handling.
- P270 Do not eat, drink or smoke when using this product.
- P281 Use personal protective equipment as required.
- P301 + P312 IF SWALLOWED: C all a POISON CENTER or doctor/ physician if you feel unwell.
- P308 + P313 IF exposed or concerned: Get medical advice/ attention.
- P330 Rinse mouth.
- P405 Store locked up.
- P501 Dispose of contents/ container to an approved waste disposal plant.
GF109203X (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-447)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Jacobson P.B., et al. (1995) J. Pharma. Exp. Ther. 275(2): 995–1002.
3. Jiang Q., et al. (2011) Mol. Biol. Cell. 22(8): 1167–1180.
4. Kuchera S., et al. (1993) Agents and Actions. 39 Spec No: C169–173.
