| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C25H32F3N3O5S |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
GGTI-286 TFA, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC50 = 2 μM) than the corresponding methyl ester of FTI-276. It selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50 values of 2 μM and >30 μM, respectively), and it also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM[1][2]. It is supplied as a white to off-white solid (C25H32F3N3O5S, MW 543.60).
Physical & Chemical Properties
| Molecular Formula | C25H32F3N3O5S |
|---|---|
| Molecular Weight | 543.60 g/mol |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | CC(C)C[C@@H](C(OC)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O.OC(C(F)(F)F)=O |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Storage | 4°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In CHO cells, GGTI-286 (10 μM; 2 and 4 h) TFA lowers the nuclear localization of β-catenin, as well as β-catenin/T cell factor-dependent transcription, in mammalian cells[2].
Western Blot Analysis[2]
| Cell Line | CHO cells |
|---|---|
| Concentration | 10 μM |
| Incubation Time | 2 and 4 h |
| Result | Reduced the nuclear b-catenin amount. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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