| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C224H349N48O69P |
| Purity | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
GIP/GLP-1 dual receptor agonist-1 acts as a dual agonist of the GIP and GLP-1 receptors. It is used in research on metabolic disorders and fatty liver diseases, including non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD)[1]. It is supplied as a white to off-white solid (C224H349N48O69P, MW 4849.42) at 98.33% purity.
Physical & Chemical Properties
| CAS Number | 2807481-02-1 |
|---|---|
| Molecular Formula | C224H349N48O69P |
| Molecular Weight | 4849.42 g/mol |
| Purity | 98.33% |
| Appearance | Solid |
| Color | White to off-white |
| Sequence | Tyr-{Aib}-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{Aib}-Leu-Asp-Lys-Ile-Ala-Gln-{Lys(AEEA-AEEA-γGlu-C19 phosphoric acid)}-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 |
| Sequence (one-letter) | Y-{Aib}-EGTFTSDYSI-{Aib}-LDKIAQ-{Lys(AEEA-AEEA-γGlu-C19 phosphoric acid)}-AFVQWLIAGGPSSGAPPPS-NH2 |
| Signaling Pathway | GPCR/G Protein |
| Storage | Sealed storage, away from moisture. Powder: -80°C, 2 years; -20°C, 1 year. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Brian Lian, et al. Compositions and methods for the treatment of metabolic and liver disorders. WO2022159395
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
GIP/GLP-1 dual receptor agonist-1 acts as a dual binder of the human GLP-1 and GIP receptors, with an IC50 of 105 nM for the GLP-1 receptor and 153 nM for the GIP receptor in the absence of HSA; binding affinity is reduced in the presence of 2% HSA[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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