| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C27H43N3O11 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Glu-urea-Glu-NHS ester is an activated N-hydroxysuccinamide (NHS) ester of Glu-urea-Glu. It can be used to synthesize small-molecule prostate-specific membrane antigen (PSMA) inhibitors, imaging agents such as PSMAi-PEG conjugates, and targeted drug delivery vehicles[1][2]. It is supplied as a white to off-white solid (C27H43N3O11, MW 585.64) at 99.51% purity.
Physical & Chemical Properties
| CAS Number | 1228927-36-3 |
|---|---|
| Molecular Formula | C27H43N3O11 |
| Molecular Weight | 585.64 g/mol |
| Purity | 99.51% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | CC(C)(C)OC(CC[C@@H](C(OC(C)(C)C)=O)NC(N[C@H](C(OC(C)(C)C)=O)CCC(ON1C(CCC1=O)=O)=O)=O)=O |
| Signaling Pathway | Immunology/Inflammation |
| Solubility | In Vitro: DMSO: 100 mg/mL (170.75 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[2]. Jung-Jae Lee. Chemiluminescent and fluorescent nanoparticle for optical imaging of cancer. WO2020081581A1. 2020-04-23.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (170.75 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
In Vivo
Choose the formulation that suits the animal model and route of administration; percentages are volume ratios of the final working solution. Start from a clear DMSO stock (see In Vitro above), add the co-solvents one at a time in the order listed, mixing after each addition, and prepare the working solution fresh on the day of dosing. If precipitation or phase separation occurs, gentle warming or sonication can help.
Protocol 1
| Composition | 10% DMSO + 90% Corn Oil |
|---|---|
| Result | ≥ 2.5 mg/mL (4.27 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). Use with caution if continuous dosing will exceed two weeks. For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 900 μL corn oil. |
Data provided by the manufacturer.
In Vitro
Small molecule prostate specific membrane antigen inhibitors can be synthesized with Glu-urea-Glu-NHS ester[1]. As a key intermediate, Glu-urea-Glu-NHS ester serves in the synthesis of small-molecule PSMAi-PEG ligands, and these ligands can be linked to fluorescent nanoparticles used for targeted optical imaging of cancer and for drug delivery[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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