| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C32H34FN5O7 |
| Activity | |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Gly-Cyclopropane-Exatecan is used in the synthesis of an anti-B7-H4 antibody-drug conjugate (ADC) and contains Exatecan, a DNA Topoisomerase I inhibitor. It contributed to the formation of the ADC hu2F7-Exatecan, which showed antitumor activity both in vivo and in vitro[1]. It has the molecular formula C32H34FN5O7 (MW 619.64).
Physical & Chemical Properties
| CAS Number | 2414254-49-0 |
|---|---|
| Molecular Formula | C32H34FN5O7 |
| Molecular Weight | 619.64 g/mol |
| SMILES | NCC(NCOC(C1CC1)C(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related; Cell Cycle/DNA Damage |
| Bioactivity Class | Camptothecins |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Hua Haiqing, et al. Anti-b7-h4 antibody-drug conjugate and medicinal use thereof: World Intellectual Property Organization, WO2020244657. 2020-12-10.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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