| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C52H55FN10O15 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide is a drug-linker conjugate for antibody-drug conjugates, containing the ADC linker Gly-Mal-GGFG and the ADC cytotoxin Deruxtecan 2-hydroxypropanamide[1]. It is supplied as a light yellow to yellow solid (C52H55FN10O15, MW 1079.05) at 99.01% purity.
Physical & Chemical Properties
| CAS Number | 2750623-07-3 |
|---|---|
| Molecular Formula | C52H55FN10O15 |
| Molecular Weight | 1079.05 g/mol |
| Purity | 99.01% |
| Appearance | Solid |
| Color | Light yellow to yellow |
| SMILES | OC(CNC[C@H](N1C(C=CC1=O)=O)C(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCO[C@@H](C)C(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O)=O)=O)=O |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related; Cell Cycle/DNA Damage |
| Solubility | In Vitro: DMSO: 25 mg/mL (23.17 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | -80°C, protect from light. |
| Shipping | Shipping with dry ice. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Zhu Yi, et al. Camptothecin derivative and ligand-drug conjugate thereof. WO2022078260A1. 2021.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 25 mg/mL (23.17 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months); protect from light; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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