| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C12H8O5 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Glycolate oxidase-IN-1, a salicylic acid derivative inhibits glycolate oxidase (GO) with an IC50 of 38.2 μM. It reduces oxalate production in hyperoxalate hepatocytes and can be used in the study of primary hyperoxaluria type 1 (PH1)[1]. It has the molecular formula C12H8O5 and a molecular weight of 232.19 g/mol.
Physical & Chemical Properties
| CAS Number | 330977-65-6 |
|---|---|
| Molecular Formula | C12H8O5 |
| Molecular Weight | 232.19 g/mol |
| SMILES | O=C(O)C1=CC(C2=CC=C(C=O)O2)=CC=C1O |
| Signaling Pathway | Metabolic Disease |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In mouse hepatocytes treated with Glycolate oxidase-IN-1(0-12.5 μM, 48 h), excreted oxalate falls significantly, by 67.3 ± 32% at 6.25 μM. At 12.5 μM, the reductions are 105.8 ± 29.2% after 24 hours and 62.3 ± 24.4% after 48 hours of treatment, with no cytotoxicity[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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